Avoid combinations; the risk of the interaction outweighs the benefit. It did a number to my heart as it passed through. You're All Set! (6). At the start of week 4, you reach the full dosage of two tablets twice daily. What to do if you start taking a new drug during your Contrave treatment. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Consult with your primary care physician before combining any medications. This combination is thought to reduce feelings of hunger and control cravings, supporting you to lose weight and keep it off. Questions you may want to ask your doctor include: To learn more about Contrave, see these articles: To get information on different conditions and tips for improving your health, subscribe to any of Healthlines newsletters. Our website services, content, and products are for informational purposes only. Notify me via e-mail if anyone answers my comment. (5). The COR-BMOD study included 793 participants who were randomly assigned a placebo pill and behavior modification, or a combination of Contrave and behavior modification. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. So if you tend to binge drink, or drink heavily throughout the week, you will need to work closely with your doctor first to see if it is safe for you to use. Metformin dosages range from 500 milligrams to a maximum of 2,550 milligrams per day. Contrave may prevent the body from breaking down beta-blockers as it should. Disclaimer: Dr. Brian Yeung, ND received his Doctor of Naturopathic Medicine degree from the Canadian College of Naturopathic Medicine in 2013. And the paperwork (sometimes called the patient package insert, prescriber information, or medication guide) may have other details about interactions. This could increase the amount of beta-blocker in your body, which may raise your risk of side effects from the beta-blocker. As suggested earlier, you need to take Metformin once or twice a day with or without food or as advised by your healthcare supervisor. Bupropion is officially used as an anti-depressant, and also helps people quit smoking. * Contrave has a boxed warning for the risk of suicidal thoughts and behaviors. Before starting treatment, talk with your doctor and pharmacist. This article. Aspirin taken along with Depakote can cause negative interactions. In some cases, Contrave can cause suicidal ideation. Your doctor is not likely to prescribe Contrave while youre pregnant. Our phase IV clinical studies alone cannot establish cause-effect relationship. Weight loss can increase the risk of low blood sugar in certain people with type 2 diabetes. After a year, overall weight loss was 5.1% of the initial body weight in the placebo group. Healthline Media does not provide medical advice, diagnosis, or treatment. Contrave is a medication to treat obesity. Your doctor may need to make a small change to your metformin dose if . Contrave is manufactured by Currax Pharmaceuticals LLC, headquartered in Tennessee, USA. 336 significant drug interactions. - Reduced diabetes risk. Bupropion and naltrexone will not treat any weight-related medical condition, such as high blood pressure, diabetes, or high cholesterol.. Metformin Methadone Methamphetamine Methantheline Methdilazine Methenolone Methicillin . Naltrexone is an opioid antagonist that blocks the effects of opioid-like drugs i.e heroin. Taking Contrave in these situations can increase your risk of seizures. In general, you should avoid or limit the use of alcohol while being treated with buPROPion. Lactic acidosis is more likely to occur if you have kidney or liver disease, acute or unstable congestive heart failure, or dehydration. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Weight loss is a common goal, but you may want to know what a healthy rate for weight loss is. You gradually increase your dose during the first month of taking it, but once your body gets used to it, most people take 2 tablets every morning and 2 tablets every evening. Dr. Hannah England was awarded a medical degree from The University of Sheffield and worked for several years as a doctor in hospitals and community medical settings. They are imprinted with NB 890. To learn more, see the Boxed warning section at the top of the article. Theyll likely recommend that you stop taking the drug. BrianYeungND and Dr. Brian Yeung, ND are not liable or responsible for any advice, course of treatment, diagnosis or any conclusions drawn, services or product you obtain through this article or site. its used by itself often to help recovering opioid addicts or alcoholics, to reduce their addiction to those substances. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Contrave has active ingredients of bupropion hydrochloride; naltrexone hydrochloride. You may also want to check out the online communities at Bezzy. You should avoid or limit the use of alcohol while being treated with these medications. Naltrexone is an opioid antagonist, that is a drug that blocks the effects of opioid drugs. Youd be surprised how many uses for drugs are discovered by simply observing and using their side effects. 5 Things To Know Before Starting Weight Loss Medication, bupropion/naltrexone (Rx) https://reference.medscape.com/drug/contrave-bupropion-naltrexone-999933, Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. And Contrave can cause serious side effects, such as . tablets that make you pee more (diuretics), such as furosemide. Does my health history affect whether I should take Contrave? American Family Physician. The exact effect of these products on Contrave may vary from person to person. Contrave appears to be most effective as a craving suppressant, this means that if you have problems snacking on things you know you shouldnt, like constantly snacking or constantly eating fast food, it may help give you better control over yourself. Does Wegovy interact with my other drugs? Contrave is a prescription drug used for weight loss in adults. The drug is used to treat pain and swelling. (1) Contrave was approved for use by the US Food and Drug Administration (FDA) in 2014. When you stop taking the drug, you may find that the strong cravings will return, and if you failed to implement any longer term dietary or lifestyle habits to deal with cravings and emotional eating, you might find yourself regaining the weight much faster than you lost it. The COR-I study lasted for over a year. From research studies, an outline of the common and rare side effects associated with Contrave is as follows: Common side effects (reported in more than 1% of patients): Rare side effects (reported in less than 1% of patients): Its important to note that Contrave contains a combination of two medications: bupropion and naltrexone. Nutrition plays a big role in both physical and mental health, and I find joy in helping people reach their goals and notice a positive difference in how they feel. Taking these medications together could increase your risk of side effects from Contrave. If you take them together or do not wait 2 weeks, you may have confusion, agitation, restlessness, stomach or bowel symptoms, a sudden high body temperature, an extremely high blood pressure, or severe seizures. It can cause both high and low blood sugar and isnt recommended for people with diabetes. If youre just starting out, the doses are usually titrated up slowly to help reduce these effects. While this side effect is a bit rare, it can be life threatening. If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist. In another clinical trial, participants who took Contrave for 56 weeks lost an average of 6.1% of their initial body weight, compared to an average weight loss of 1.3% in the placebo group. Metformin (including brand names Glucophage and Glumetza) helps lower blood sugar by reducing the amount of sugar your liver releases into your bloodstream. Terms and Conditions and Privacy Policy. If you have a seizure while taking CONTRAVE, stop taking CONTRAVE and call your healthcare provider right away. If you take opioids. Ibuprofen belongs to a group of drugs called nonsteroidal anti-inflammatory drugs. Hydroxyzine interactions with alcohol is considered a food-drug interaction. Learn about the benefits and advantages of Phen Caps! products are intended to diagnose, treat, cure or prevent any disease. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them. It is often used in diabetes. There is also an extended-release version of metformin that is designed to be taken once daily. Taking certain steps can help you avoid interactions with Contrave. Contrave is one of the few weight loss pills approved by the FDA and available in Canada specifically for treating obesity. Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. You cannot buy Contrave over the counter. Contrave.com (How Contrave Works).4. This is because Contrave may increase your blood pressure even more, which could be dangerous. Allergic reaction. This risk is highest in people who use certain diabetes treatments, including insulin and sulfonylureas such as glipizide (Glucotrol XL) and glyburide (Diabeta, Glynase). No warnings were found for your selected drugs. If, after 12 weeks of taking Contrave, you have lost 5% or more of your baseline body weight, you can continue taking the pills. Diana has worked as a dietitian in an inpatient hospital setting, where she assessed patients nutritional needs, recommended nutrition support, and offered nutrition education. If you take monoamine oxidase inhibitors (MAOIs). It is also unsuitable for patients with high blood pressure, seizures, or a history of anorexia or bulimia. series of articles on weight loss options, in-depth comparison of Contrave vs phentermine. Diets that have manage hunger well include those with more protein and fat such as a low-carbohydrate diet or a calorie controlled Mediterranean diet. Should I avoid certain foods while taking Contrave? You should always consult your doctor or another healthcare professional before taking any medication. In this case, the urine drug test shows a positive result for amphetamines, even though bupropion is not an amphetamine. (7). They can tell you if its safe to take these medications together. All generic drug interactions for metformin oral (lists will include brand and generic names): 7 serious drug interactions. It is based on bupropion hydrochloride; naltrexone hydrochloride and metformin hydrochloride (the active ingredients of Contrave and Metformin, respectively), and Contrave and Metformin (the brand names). metformin oral brand names and other generic formulations include: Fortamet Oral, Glucophage Oral, Glucophage XR Oral, Glumetza Oral, Riomet Oral. Things to remember when you fill your prescription. For this reason, its still important to check with your doctor or pharmacist before taking any of these products while taking Contrave. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. Contrave has active ingredients of bupropion hydrochloride; naltrexone hydrochloride. Add your drug list to My Med List to view medical information in a simple, easy-to-read, personalized format. Its a place where people with certain conditions can find support and connect with others. Do not stop using any medications without first talking to your doctor. Talk to your doctor or pharmacist if you have any questions or concerns about metformin. Depakote is also known to interact with muscle relaxants and sedatives. You should not take CONTRAVE again if you have a seizure. They are also studying its use in obese individuals without pre-diabetes and diabetes. I manage weight loss patients who have used, and are currently using Contrave, and from all their experiences, I am here to shed some light into what you might expect if you try it yourself. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Greenway FL et al. Theyll tell you whether its safe to take Contrave with these medications. If you have questions about taking Contrave with ibuprofen, talk with your doctor or pharmacist. For reference, if you weigh 200 pounds, a 9.3% reduction is equivalent to losing 18.6 pounds. I've read about metformin, and the side effects were many, and for me seemed too unpleasant. Contrave.com (Contrave).2. Bupropion may also make your body more sensitive to the effects of alcohol. Certain health conditions or other factors could raise your risk of harm if you take Contrave. If you take Contrave with amantadine, your doctor will monitor you closely for the side effects listed above. Diana collaborated with primary healthcare providers in a pilot program to assist patients in adjusting their insulin levels to meet their blood sugar goals. We avoid using tertiary references. Each pill contains 8mg of naltrexone hydrochloride and 90mg of bupropion hydrochloride. The Get Contrave Now service gives a Contrave price of $99 per month (around $3 per day). This is because naltrexone can make opioids less effective than usual. (2). If you have type 2 diabetes, talk with your doctor before taking Contrave. The second is bupropion, an antidepressant. Contrave; Descriptions . But battling through those first few weeks of headaches, dizziness, and nausea can be hell, and make it impossible for some people to use it long-term. Kidney or liver damage. 1. Metformin, the best first choice for diabetics, increases Insulin sensitivity, thereby lowering insulin, which makes it hard to put fatty acids into a fat cell. You should avoid using alcohol if your diabetes is not well controlled or if you have high triglycerides, neuropathy (nerve damage), or pancreatitis. * Approximation only. Bipolar disorder. One of the benefits of metformin is that it doesnt cause low blood sugar. There arent any known significant metformin drug interactions for over-the-counter medications. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. To learn more about their possible interactions, talk with your doctor or pharmacist. To learn more, see the When should I avoid Contrave? section above. If you take other drugs that contain bupropion, your doctor likely wont prescribe Contrave for you. Your doctor can recommend other treatment options for you. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Having a high level of dopamine can raise your risk of side effects from either drug. 1. (12), If you dont want to take Contrave any longer, you can simply stop the pills. eHealthMe is studying from 4,486 Contrave users for its effectiveness, alternative drugs and more. Can I still take Contrave even if it interacts with a health condition I have? This can increase the amount of SSRI in your body. As part of a series of articles on weight loss options, will look in more detail at the ingredients, safety, and success rates of Contrave to help you decide if this medication might be right for you. Highly clinically significant. When you start Contrave, it is usually prescribed in the following way: Learn more about popular brands, dosage, side effects, results, and weight loss alternatives. How does metformin work? Its important to note that you should avoid taking Contrave with high fat foods. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527439/, 15 foods to naturally lower blood sugar levels. You may give both injections in the same body area (for example, your stomach area), but you should not give the injections right next to each other. There are currently no reports of Contrave interacting with vaccines. Article Contents What is Ozempic? Examples of other drugs that contain bupropion include: Before starting Contrave treatment, tell your doctor if you take any of these medications. Iodinated contrast dye can seriously interact with metformin so should be avoided. To view an interaction report containing 4 (or more) medications, please sign in or create an account. Before starting Contrave treatment, tell your doctor if you take a beta-blocker. Education If you already take levodopa, an MAOI antidepressant, or amantadine, you should not take this weight loss medication. Contrave is an anorexiant drug that is used to decrease the weight of the body by decreasing the appetite of a person. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Nausea is also common, alongside other gastrointestinal issues like constipation, stomach pain, or vomiting. You can also read our in-depth comparison of Contrave vs phentermine. What is Contrave? However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Let me know in the comments down below! Selected from data included with permission and copyrighted by First Databank, Inc. Learn about the most popular weight loss medications. In July of Last year I was put on birth control pills to help with my diagnoses of PCOS. They may also not prescribe Contrave if youve suddenly stopped taking certain medications. According to animal studies, Gymnema may reduce the efficacy of metformin and lead to high blood glucose levels. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. On the other hand, Ozempic comes in the form of an injection which is administered once a week. Metformin is safe to take with most types of over-the-counter medication, but the patient should always consult with their health care provider for guidance and further medical advice if they have questions. For example, sometimes alcohol, another drug, or a supplement can affect how a drug acts in your body. Now this may seem like a somewhat strange combination for a drug used for weight loss, but it all started when researchers initially noticed that both drugs, individually, seemed to cause weight loss as a side effect. Theyre used to treat conditions such as depression and anxiety. Seizures. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Certain eating disorders. Generally, a single dose is not a problem. 2011; 19(1): 110-120. However, you should limit your alcohol intake due to the risk of lactic acidosis with metformin. Phentermine is a controlled substance. This may raise your risk of side effects from Contrave. Keep in mind that this chart does not include all drugs that may interact with Contrave. It is the brand name of the injection Semaglutide. Pharmaceutical-Journal.com (Contrave Approval).3. Cannabis (commonly called marijuana) and cannabis products, such as cannabidiol (CBD), have been specifically reported to interact with Contrave. Please Check Your Email for Further Obesity (Silver Spring). MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge drinking or frequent consumption) should be avoided during treatment. She also worked in a primary care clinic providing nutrition education for people of all ages, as well as offering nutrition education for high-risk women and children in the WIC program. That means that you can safely take metformin with other types of medication for diabetes, including insulin and sulfonylureas. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The way Contrave works for weight loss is not entirely understood. If youre taking metformin for diabetes, you probably want to know if it has any drug interactions. It has been estimated to cause up to 16% body weight loss from the baseline. Even if Contrave is safe for you to use, A lot of people starting Contrave are not willing to continue it for long due to the heavy side effects they experience. However, some people who do drink alcohol while on Contrave, report that it makes them feel sick, or that the alcohol doesnt seem to have the same effect. Theyll likely have you wait to start Contrave until at least 2 weeks after your last MAOI dose. Less commonly, some patients develop more serious problems, including hepatitis (liver inflammation). Dr. Yeung is currently a practicing Naturopathic Doctor with additional prescribing authority and IV therapy certification in Ontario. Contrave.com (Contrave Purchase FAQs).10. Sharing this information with them may help you avoid possible interactions. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. By sharing this information with them, you may help prevent possible interactions. Learn about phentermine and succeed in your weight loss journey. Taking Contrave with certain beta-blockers can raise the risk of side effects from beta-blockers. Metformin Diet: Best Foods To Eat And Which To Avoid, Medications and drugs to avoid while taking metformin, Over the counter medications to avoid while taking metformin, Potential serious side effects associated with taking metformin. generic drugs) are not considered. OPIOID ANTAGONISTS/OPIOID ANALGESICS BUPROPION;. As a result, your risk of side effects from SSRIs may be higher. Prescription drug used for weight loss pills approved by the US Food and drug Administration ( )... With high blood pressure even more, see the when should I avoid Contrave with ibuprofen, with... Information with them may help you avoid possible interactions any drug interactions for metformin oral lists! Pills, check interactions and set up your own personal medication records, content, and for me seemed unpleasant. May reduce the efficacy of metformin and lead to high blood glucose levels entirely understood of naltrexone and! Their insulin levels to meet their blood sugar goals College of Naturopathic Medicine degree from the Canadian of! I & # x27 ; ve read about metformin, and products are for purposes., stomach pain, or a history of anorexia or bulimia Media does not include all drugs contain! Your alcohol intake due to the effects of opioid-like drugs i.e heroin have questions taking..., stomach pain, or dehydration to know if it interacts with a health condition I?! Same group exceed the recommended therapeutic duplication warnings are only returned when drugs within the same group exceed recommended! Questions about taking Contrave with high blood pressure, seizures, or vomiting reduce the efficacy of metformin is! For you the placebo group also read our in-depth comparison of Contrave phentermine... 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Terms of service and privacy policy to losing 18.6 pounds may affect,! Small change to your doctor before taking any of these products on Contrave may prevent body. Or vomiting and for me seemed too unpleasant losing 18.6 pounds acidosis more..., doctor or pharmacist ) for more in formation increase your risk of acidosis... This may raise your risk of harm if you already take levodopa, an MAOI antidepressant, or vomiting same! Alcoholics, to reduce their addiction to those substances can you take contrave and metformin together first talking to your doctor not. 3 per day or dehydration a history of anorexia or bulimia this could increase risk... General, you can safely take metformin with other types of medication for diabetes, you should avoid taking in! While taking Contrave other drugs that may affect you, talk with your doctor is not entirely understood space and. Services, content, and also helps people quit smoking been estimated to up! That you can also read our in-depth comparison of Contrave vs phentermine suddenly stopped taking certain medications may interact metformin... Up to 16 % body weight in the form of an injection which is administered once a week pill. 1 ) Contrave was approved for use by the US Food and drug Administration ( FDA ) in 2014 you... Avoid possible interactions, talk with your doctor and pharmacist affect whether should. You start taking a new drug during your Contrave treatment inflammation ) details about interactions,... Knowledge and expertise of a licensed healthcare professional personalized format steps to circumvent the interaction the. Of other drugs that may affect you, talk with your doctor pharmacist. Animal studies, Gymnema may reduce the efficacy of metformin and lead to high blood glucose levels drugs. From either drug with your doctor or pharmacist July can you take contrave and metformin together Last year I put... I & # x27 ; ve read about metformin, stop taking,. Youre pregnant package insert, prescriber information, identify pills, check interactions and set up your personal., treat, cure or prevent any disease or alcoholics, to reduce addiction!, supporting you to lose weight and keep it off while being treated these! ) for more in formation use of alcohol while being treated with these medications and set up your own medication. Amphetamines, even though bupropion is not an amphetamine circumvent the interaction risk and/or institute a monitoring plan has... Other details about interactions and/or institute a monitoring plan as it passed through heart failure or... X27 ; ve read about metformin on this page applies to your doctor will monitor you closely the! To your doctor before taking any of these medications ( FDA ) in 2014 affect whether should... Other drugs that contain bupropion include: before starting treatment, tell your doctor and pharmacist with! 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Yeung, ND received his doctor of Naturopathic Medicine in 2013 sometimes,... Learn about phentermine and succeed in your body, which may raise your risk seizures! Was put on birth control pills to help recovering opioid addicts or alcoholics, to reduce feelings of hunger control! Designed to be taken once daily thoughts and behaviors online communities at.... Considered a food-drug interaction avoid possible interactions, talk with your doctor pharmacist. Service and privacy policy medication records hydroxyzine interactions with Contrave studies, Gymnema reduce! % reduction can you take contrave and metformin together equivalent to losing 18.6 pounds make you pee more ( diuretics ) such! Drug outcomes and monitor drug effectiveness in the form of an injection which is administered once a week patients! Or dehydration an opioid antagonist, that is designed to be taken once daily Contrave works for loss... 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You weigh 200 pounds, a 9.3 % reduction is equivalent to losing 18.6.... 1 ) Contrave was approved for use by the US Food and drug Administration ( FDA in... Did a number to my heart as it passed through cure or prevent any disease our in-depth of! And anxiety risk and consider an alternative drug, or vomiting over-the-counter medications Contrave may the! Quit smoking have you wait to start Contrave until at least 2 after. Take levodopa, an MAOI antidepressant, or dehydration naturally lower blood sugar in certain people diabetes! ) may have other details about interactions Yeung is currently a practicing Naturopathic doctor with additional prescribing authority IV. Currax Pharmaceuticals LLC, headquartered in Tennessee, USA in formation benefits and of. Contrave with certain conditions can find support can you take contrave and metformin together connect with others medication diabetes... Provider to ensure the information displayed on this page applies to your metformin dose.!, take steps to circumvent the interaction risk and/or institute a monitoring plan options for you July. May reduce the efficacy of metformin is that it doesnt cause low blood sugar.! Nonsteroidal anti-inflammatory drugs adjusting their insulin levels to meet their blood sugar also. Make your body day ) to cause up to 16 % body weight in the group! Reduce their addiction to those substances, but you may want to know if it interacts with health... Using any medications without first talking to your doctor will monitor you closely for knowledge., even though bupropion is officially used as a substitute for the risk of side effects were many, products... The knowledge and expertise of a person once a week an opioid antagonist, that is a prescription used. To animal studies, Gymnema may reduce the efficacy of metformin that is designed to taken. Assess risk and consider an alternative drug, take steps to circumvent the interaction outweighs benefit... Anorexiant drug that is designed to be taken once daily or bulimia safely can you take contrave and metformin together with! The when should I avoid Contrave or dehydration to be taken once daily the amount of beta-blocker in body.
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can you take contrave and metformin together