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PLoS One. What is the potential role of antifibrotic agents for the treatment of liver disease? Mol Cell Biol. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. 1996 Dec 15; 98(12):2771-8. 1990 Feb; 10(1):75-83. Nat Clin Pract Gastroenterol Hepatol. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. 2017 May 02; 25(5):1054-1062.e5. Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Goto M, Yamashina S, Schemmer P, Kitamura T, Oide H, Takei Y, Hirose M, Shimizu H, Miyazaki A. c-Jun does not mediate hepatocyte apoptosis following NFkappaB inhibition and partial hepatectomy. 2022 10; 610(7931):366-372. 2016 Sep; 92(3):84-92. 1994 Oct; 267(4 Pt 1):G552-61. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. 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Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. 2006 May; 130(6):1564-72. Hepatology. Brenner has also been listed as a lead researcher on UCSDs portion of the liver study. 2013 Jul; 145(1):16-31. 1989 May; 9(5):2224-7. 2006 Apr; 290(4):G583-9. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. 2008 Nov; 48(5):1420-9. 2003 Apr; 27(4):726-31. J Clin Invest. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. Hepatology. Liedtke C, Plmpe J, Kubicka S, Bradham CA, Manns MP. 2012 Sep; 143(3):765-776.e3. 1998 Sep; 13 Suppl:S39-50. J Hepatol. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. 1990; 14(6):639-45. 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Brenner, MD, has served as Vice Chancellor of Health Sciences and Dean of the School of Medicine at UC San Diego since 2007. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). Curr Opin Gastroenterol. Enomoto N, Yamashina S, Schemmer P, Rivera CA, Bradford BU, Enomoto A. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. 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Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. J Gastroenterol Hepatol. 2001 Jan; 33(1):81-90. 2009 May; 40(5):1721-8. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. What's new in liver fibrosis? Stroke. Hepatology. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. Am J Physiol. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. J Biol Chem. Hepatology. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. JCI Insight. 2014 Apr 29; 63(16):1626-33. 1993 Feb; 17(2):287-92. 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Signal transduction during liver regeneration. 2000 Dec; 32(6):1255-64. People who share similar concepts with this person. Transplantation. 2007 Jun; 132(7):2601-4. 2012 Jun 12; 109(24):9448-53. Contribution of bone marrow-derived fibrocytes to liver fibrosis. Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. Liver Transpl. Cell Metab. 1979 Sep-Oct; 52(5):449-54. 2021 07 20; 118(29). 1990 Apr; 7(2):105-15. Colmenero J, Bataller R, Sancho-Bru P, Domnguez M, Moreno M, Forns X, Bruguera M, Arroyo V. CCR2 promotes hepatic fibrosis in mice. Circ Res. 2005 Apr 08; 280(14):13374-82. Ital J Gastroenterol Hepatol. 2014 Dec; 26(12):1802-11. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. Carethers will report directly to the chancellor and is part of the leadership team. Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. 1999; 8(3):151-63. 1994 Jul 29; 269(30):19203-6. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. 2007 Aug; 22(8):1256-64. 2009 Jan 16; 378(3):348-53. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. Am J Respir Cell Mol Biol. 2007 Dec; 52(12):3404-15. This site is running Profiles RNS version pre_new_search-4-g7119b7be on PROFILES-PWEB04. J Biol Chem. Gastroenterology. Hepatology. Hepatology. J Biol Chem. Download Bio Dr. David Brenner is vice chancellor for health sciencesat the University of CaliforniaSan Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences,Herbert Wertheim SchoolofPublic Healthand Human Longevity Science, and UC San Diego Health. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. 2013 Sep 16; 202(6):951-66. 2014 Dec; 60(6):1920-8. 2014 Jul; 124(7):2921-34. J Hepatol. 2014 Mar 07; 289(10):7082-7091. Blood. 2008 Dec; 48(6):2016-26. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. We lose people all of the time. Am J Physiol Gastrointest Liver Physiol. 1994 Dec; 124(6):755-60. Hepatology. Recent advancement of molecular mechanisms of liver fibrosis. Mol Cell Biol. 2020 05; 72(5):946-959. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. Am J Physiol. 2018 09; 68(3):918-932. Mol Cell Biol. 2007 Dec 07; 249(3):518-31. WebBrenners new job suits his eclecticism. 2017 Feb 01; 312(2):C131-C143. 2017 01 03; 127(1):55-64. Genomics of liver fibrosis and cirrhosis. Acceptance Post-Bac. 2020; 4(5):561-580. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y. Molecular pathogenesis of liver fibrosis. # # # Media Contact: Alma Fisher, 619-543-6163, alfisher@ucsd.edu Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Hepatol Res. Role of NADPH oxidases in liver fibrosis. He did not respond to inewsource s interview request. Gastroenterology. Hepatology. Nat Rev Gastroenterol Hepatol. 1997 May; 25(5):1128-35. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. Cancer Res. See more options in the Advanced Search tab. Toxicol Sci. 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Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. 2002 Dec; 36(6):1498-508. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. 2001 Nov; 34(5):953-63. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Lemasters JJ, Qian T, Trost LC, Herman B, Cascio WE, Bradham CA. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. Cell Death Differ. Exp Biol Med (Maywood). 1977 Dec; 60(6):1354-61. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. 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Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Int Psychogeriatr. Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. Cell Death Differ. J Biol Chem. Hepatology. Ann Hepatol. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical J Biol Chem. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. 2006 Aug; 116(8):2058-9. Am J Gastroenterol. 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Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. 2021 11; 25(11):2149-2159. Science. 2004 Aug 01; 173(3):1561-70. 2015 Sep; 39 Suppl 1:S75-9. DavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective February 1, 2007. Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. 2001 Aug; 21(3):437-51. 2002 Oct; 4(5):769-81. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. J Hepatol. 2017 02; 152(3):598-607.e2. 2012 Nov; 13(11):1072-82. Brain Commun. Role of Gut Microbiota in Liver Disease. 1999 Oct 22; 274(43):30919-26. 2010 Oct; 8(10):891-8, 898.e1-2. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. Am J Physiol Gastrointest Liver Physiol. Aging Ment Health. 1999 03; 276(3):G591-8. The gut-liver axis and the intersection with the microbiome. Liver Transpl. Le TA, Chen J, Changchien C, Peterson MR. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. J Hepatobiliary Pancreat Sci. 2009 Jan; 130(1):16-26. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Gut. 2018 09; 68(3):1070-1086. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. Biochem Biophys Res Commun. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. 2002 Jul; 283(1):G204-11. 2013 Feb; 57(2):577-89. 2006 Oct; 21 Suppl 3:S84-7. 2003 Jan 01; 8:d69-77. 2001 Jun 01; 166(11):6812-9. Hepatol Commun. 2014 Oct; 27(5):413-25. 1990 Dec; 9(10):777-81. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. 1985 Apr; 5(4):684-91. 2019 01; 49(2):183-193. 2013 Feb 01; 12(3):381-2. J Biol Chem. Hepatology. Gastroenterology. Nat Med. Nat Med. Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW. Biochem Biophys Res Commun. 2008 Nov; 135(5):1729-38. 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