intradiscnutrosis what is it

Functional and disability outcomes were also improved statistically and clinically; 55 % of the IDB + CMM patients responded to treatment with a mean VAS reduction of 2.2 points at 12 months. 2021;13:1759720X211028001. In addition, both ODI and BDI data were trending positive and a majority of patients reported improvements in their DPQ scores. Furthermore, the satisfaction rate was higher in patients receiving greater than 10 PRP compared to those receiving less than 5 PRP (81 % versus 55 %; p = 0.032). The doctor fits you with a harness around your pelvis and another around your trunk. Lu Y, Guzman JZ, Purmessur D, et al. It can be difficult to determine who will benefit from spinal decompression surgery. , he carefully explained the process that causes disc herniation or bulging and the mechanism by which this can be healed. Monfett M, Harrison J, Boachie-Adjei K, Lutz G. Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: An update. 2002;27(22):2621-2626. The bottom line, he said, is that more study is needed. Intradiscal RF lesioning was carried outin the middle and posterior portion of the cervical disc at 85 degrees C for 10 mins. A randomized, placebo-controlled trial of transdiscal radiofrequency, biacuplasty for treatment of discogenic lower back pain. Singh V. Percutaneous disc decompression using Nucleoplasty. But it's not for everyone, including those with spine tumors, osteoporosis, infection, cancer, severe and unstable spondylosis (spinal arthritis), and many other conditions. The primary drawback was the relatively small sample size; 5 patients dropped-out after being enrolled by prior to randomization; selection bias was possible but not dissimilar to other studies of procedural interventions in which individuals may elect for additional non-invasive care prior to undergoing intervention. Decision memo for thermal intradiscal procedures (CAG-00387N). Ceylan A, Ak . Apparently, that depends on whom you ask, and under what circumstances the treatment is performed. Effectiveness of intradiscal injection of radiopaque gelified ethanol (DiscoGel) versus percutaneous laser disc decompression in patients with chronic radicular low back pain. The Oswestry improved from 23.3 (SD 7.0) to 16.5 (6.8) points at 1 month and remained similar after 6 months. Thus, single-site, long-duration cervical intradiscal RF lesioning in vivo can not be recommended. 2021;7(3):817-840. The authors concluded that this case report was the 1st to suggest that intradiscal condoliase injection could be a useful and novel conservative therapeutic option for the treatment of post-operative rec-LDH. Stem Cell Res Ther. Between-group comparison of NRS scores after 2 follow-ups were not statistically different (p = 0.62); however, the ODI score in DiscoGel was statistically lower (p = 0.001); 6 cases (16.67 %) from each group reported undergoing surgery after the follow-up period, which was not statistically different. The Nerve & Disc Institute has helped lots of patients end the pain and get their life back. Percutaneous radiofrequency ablation for facet-mediated neck and back pain. The fat was separated to isolate the SVF and the cells were delivered into the disc nucleus of patients with DDD. The critique stated that the conclusions of this systematic evidence reviewwere non-specific. Nezer D, Hermoni D. Percutaneous discectomy and intradiscal radiofrequency thermocoagulation for low back pain: Evaluation according to the best available evidence. A TE of 20 ms yielded the best CNR. The authors concluded that intradiscal O2-O3 chemonucleolysis for single-level lumbar disc herniations unresponsive to medical management, met the non-inferiority criteria to microdiscectomy on 6-month mean leg pain improvement. Dyer tells his patients to engage only in walking during the month-long recovery process. Curr Rev Pain. Dall'Olio and colleagues (2014) noted that intradiscal oxygen-ozone (O2-O3) chemonucleolysis has been used for the treatment for pain caused by protruding disc disease and nerve root compression due to bulging or herniated disc. Radio-frequency (thermo) lesions in lumbosacral spinal column - primary research. IP181. Sedation was performed in the prone position in the operating room, and a C-arm was located so as to provide a lateral view of the surgical field. 2014;4(5):e19206. This approach can only be performed once in a lifetime; thus, understanding the factors that determine the indication for the use of condoliase and predict outcomes is important. font-size: 18px; ", The clinician also plays an important role. Davis et al (2019) stated that as a follow-up to the 6-month report, these investigators examined the analgesic effect of C-RFA in patients with knee osteoarthritis (OA) 12 months post-intervention and its ability to provide pain relief in patients who experienced unsatisfactory effects of intra-articular steroid injection (IAS); 78 % (52/67) of patients originally treated with C-RFA were examined at 12 months, while at 6 months post-IAS, 82 % (58/71) of those patients crossed-over to C-RFA and examined 6 months later. For MSCs, the aggregate success rate at 6 months was 53.5 % (95 % CI: 38.6 % to 68.4 %), though using worst-case analysis this decreased to 40.7 % (95 % CI: 28.1 % to 53.2 %). Ukeba et al (2022) noted that lumbar intervertebral disc (IVD) herniations are associated with significant disability. "There are some studies suggesting that VAX-D is effective. Excellent or good patient satisfaction was achieved in 87.9 % of patients after 1 week, 72.4 % after 1 year, 67.7 % after 3 years, and 63.4 % at the last follow-up. The authors concluded that as in the lumbar spine, intradiscal cervical RF provides too focal a thermal profile to effectively denervate the disc even in an ex vivo experiment. IntraDiscNutrosis program; Koren Specific Technique; Manipulation for infant colic; Manipulation for internal (non-neuromusculoskeletal) disorders (Applied Kinesiology); Manipulation Under Anesthesia (see CPB 0204 - Manipulation Under General Anesthesia ); Moire Contourographic Analysis; Network Technique; Neural Organizational Technique; Nguyen C, Boutron I, Baron G, et al. ECRI Institute. The procedure is suggested to be an alternative to spinal fusion surgery in which the disc is destroyed and the two vertebrae are fused together. Conservative medical management (CMM) was not standardized and the physicians were allowed to treat their patients based on personal clinical preferences. OL LI { None of the studies reported major complications related to Nucleoplasty. A randomized, double-blind, controlled trial intradiscal electrothermal therapy versus placebo for the treatment of chronic discogenic low back pain. Bulging or herniated disks or degenerative disk disease, Worn spinal joints (called posterior facet syndrome), Electrical stimulation (electric current that causes certain muscles to contract). Patients with a history of chronic LBP and DDD of the lumbar spine who met inclusion and exclusion criteria were recruited between December 2010 and January 2012. Buenos Aires, Argentina: Institute for Clinical Effectiveness and Health Policy (IECS); 2005. Guo X, Ding W, Liu L, Yang S. Intradiscal methylene blue injection for discogenic low back pain: A meta-analysis. Create an account to follow your favorite communities and start taking part in conversations. 2009;12(1):207-232. The authors also reported, "Transient radiculopathy (less than 6 weeks) was reported in 4 study participants who underwent IDET and in 1 study participant who underwent the sham procedure." If they really are a rip off then I hope they get closed. A total of 63 subjects were originally randomized to the IDB + CMM group (n = 29) or CMM-alone (n = 34). 2012;39(3):517-523. Second, the silk scaffolds for different tissues are varied, but the optimal silk scaffold strategy for a particular tissue is still undetermined, which has created considerable obstacles to the clinical applications of silk scaffolds. In a prospective, multicenter pilot study, Kelekis et al (2021) compared the non-inferiority treatment status and clinical outcomes of intradiscal O2-O3 with microdiscectomy in patients with refractory radicular leg pain due to single-level contained lumbar disc herniations. The American Society of Interventional Pain Physicians (ASIPP) guidelines on "Responsible, safe, and effective use of biologics in the management of low back pain" (Navani et al, 2019) stated that there is Level III evidence for intradiscal injections of PRP and MSCs. Finally, RFA represents a treatment that is implemented with the goal of long-term treatment; these investigators measured a primary outcome at 6 months, and did not follow subjects beyond this time period, but future study would ideally capture outcomes at a post-RFA time point of at least 1 year. An historical perspective. Subjects and coordinators were blinded to randomization until 6 months. Mills -- places that do only VAX-D -- tend to be profit motivated. There were several drawbacks with this study: In a feasiblity study, Dreyfussand colleagues(2008)examined if single-site, long-duration intradiscal radiofrequency (RF) at2 different positions could generate adequate heating throughout the intervertebral disc to potentially ablate intradiscal nociceptors. Copyright 2019 | THE DISC INSTITUTE OF PITTSBURGH, Proven Results with Before and After MRIs, FDA Cleared (approval not required because it is non-invasive and proven safe), Can Cause a 21% Increase in Spinal Fractures, Removes Healthy Spinal Supporting Bone to get to the Disc, Removes Bone Connecting Ligaments to get to the Disc, Minimally Invasive surgery is still invasive. Therefore, we propose that TIPs are not reasonable and necessary.". I tried physical therapy, yoga, spinal injections and none of those helped at all. Spine. "I canceled my surgery date and never rescheduled," Reiner says. These include: You are fully clothed during spinal decompression therapy. This procedure relies on a patented technology referred to as Coblation, in which the SpineWand applies a high-frequency electric current directly to the saline medium inside the disc, generating a tightly focused field of highly energized molecules around the tip of the wand. The Nerve & Disc Institute's IntraDiscNutrosis (using DiscLogix) treatment program is a medical breakthrough for people suffering from bulging discs, herniated discs, degenerative disc disease, stenosis, sciatica, and other disc-related symptoms. Patient 2 continued with significant use of opioids (100 microg/hr of transdermal fentanyl). Data were compared between baseline and at 1, 3, 6, and 12 months post-treatment. The PRF treatment was administered at 2-Hz and a 20-ms pulsed width for 20minutes at 60 V with the constraint that the electrode tip temperature should not exceed 42 C. At the 2-week, and 1-month follow-up visits, the patient's pain was completely relieved. Ong D, Chua NH, Vissers K. Percutaneous disc decompression for lumbar radicular pain: A review article. The study's glaring problem? Report ITB No. These include but are not limited to: prolonged sitting or standing, jerking motions such as those from sneezing and laughing, and bending backward. An electronic search of the literature was performed using the Cochrane Library database (2007) and Medline (1966 to 2007); 77 references relating to IDET, 363 to percutaneous discectomy, and 36 to Nucleoplasty were identified. Park CH, Lee KK, Lee SH. Arch Phys Med Rehabil. Treating providers are solely responsible for medical advice and treatment of members. Patients with greater concentrations of CFU-F (greater than 2,000/ml) and CD34+ cells (greater than 2 million/ml) in BMC tended to have significantly better clinical improvement. Exercise does nothing for an intradisk lesion or a herniated disk. Disc nucleoplasty (also known as percutaneous radiofrequency thermomodulation, percutaneous plasma discectomy or plasma disc decompression [PDD]) is a minimally invasive procedure to treat individuals with symptomatic low back and leg pain caused by herniated discs. Contact us to see if you qualify for treatment. Intradiscal injections of biologic agents such as PRP or SC are theorized to have regenerative properties and have gained increasing interest as a possible treatment; however, the evidence supporting their use in clinical practice is not yet well-defined. This study had a 12-month follow-up and enrolled 10 eligible chronic LBP patients. A total of 53 patients enrolled, of whom 4 patients dropped out. Systematic review of IDET identified 2 RCTs and 16 observational studies with an indicated evidence of Level II-2. The authors concluded that based on this preliminary data, Nucleoplasty seems to be associated with short-term increased pain at the needle insertion site and increased pre-procedure back pain and tingling numbness but without other side effects. INTRADISCNUTROSIS - Trademark Details. IntraDiscNutrosis is a combination of treatments that can create an increase of needed circulation to the disc, which allows the disc to heal and repair. The authors concluded that nucleoplasty and Dekompressor have a weak positive recommendation for the treatment of patients with lumbar radicular pain. text-decoration: underline; However, all the studies suffer from the same methodologic flaws. the absence of a control (placebo) group. "A randomized (comparison) trial is urgently needed before we expose patients to a technique that has not been (rigorously) evaluated," Carey said. In the early stages of investigation, IDET appears promising; however, additional prospective, randomized controlled clinical studies are needed to compare efficacy against other intradiscal heating procedures, to determine the precise pathology most successfully treated by the procedure, and to assess the long-term outcomes of this procedure as compared to other more conventional therapies. This review was limited to articles on musculoskeletal TE that were published in English from 2010 to September 2019. Improvements in VAS and RDQ were sustained at an average of 5.9 years after the intradiscal injection of PRPr (p < 0.01 versus baseline, respectively). During the procedure, two probes are inserted into each side of the disc. These investigators carried out comprehensive literature search in 2018 and updated in 2020. Anesth Pain Med. outline: none; "There need to be better studies before I would be comfortable believing that it's an effective part of a treatment regimen," Mazanec says. New and Emerging Technology Briefing. Pain Physician. Rev. } There were significant differences among the pre-operative, 1-week post-operative, and 3-year post-operative VAS and ODI scores, but not between the 3- and 5-year post-operative scores. 2018;21(1):E71-E78. hr.separator { Their proprietary treatment protocol, IntraDiscNutrosis, helps enable your bodys natural abilities to HEAL your bad disc. There were no significant differences in demographic variables (p > 0.05). The mean age was 37.9 years (21 to 53 years). Spine. The quality assessment and clinical relevance criteria utilized were the Cochrane Musculoskeletal Review Group criteria for interventional techniques for randomized trials, and the criteria developed by the Newcastle-Ottawa Scale criteria for observational studies. A 26-year old man presented with a NRS score of 7 for chronic neck pain. At 1 month after the intervention, the percentage of responders (LBP intensity less than 40) was higher in the GC-IDI group (36 of 65 [55.4 %]) than the control group (21 of 63 [33.3 %]) (absolute risk difference, 22.1 percentage points [95 % CI: 5.5 to 38.7 percentage points]; p = 0.009). "I'm sure I'll have a flare-up here and there, and I'll know where to go," he says. IntraDiscNutrosis is a completely unique form of treatment that turns on the disc's self-repair process; it is not physical therapy, chiropractic, pain management, epidural injections, or spinal surgery. Ogbonnayaand colleagues(2013) evaluated the effectiveness of nucleoplasty in the management of discogenic radicular pain. Two patients had increased symptoms and opted for surgery. Desai et al (2017) reported the 12-month outcomes of subjects treated with intra-discal biacuplasty (IDB) and conservative medical management (CMM) for chronic low-back pain (LBP) of discogenic origin, and results for subjects who elected to receive IDB + CMM 6 months after CMM-alone. The authors concluded that this systematic review illustrated limited to fair evidence for nucleoplasty in managing radicular pain due to contained disc herniation. At 2, and 3 months after intradiscal PRF, the pain was scored as NRS 2. There is no pain during treatment, no side effects, and no need to take downtime or recovery time off of work. Evaluation of the 42 patients demonstrated significant improvement rate of VAS: defined as 66.2 % in back pain, 68.1 % in leg pain, and 85.7 % in numbness at 1-week after the operation; 53.2 %, 58.4 %, 81.0 % at 1-year; and 45.5 %, 50.7 %, 75.0 % at 2-year follow-up. According to the Mayo Clinic, Sciatica refers to pain that radiates along the path of the sciatic nerve, which branches from your lower back through your hips and buttocks and down each leg. Chiropractic and Osteopathy, 2007. Third, currently, the research on silk scaffolds is still limited to animal experiments, and even large animals have relatively few studies. Ultra-purified stem cells with an in situ-forming bioresorbable gel for enhancement of intervertebral disc regeneration. Pain Pract. Injection of intradiscal o2-o3 to reduce pain and disability of patients with low back pain due to prolapsed lumbar disk. Spinal decompression works by gently stretching the spine. All rights reserved. The Disc Institute of Pittsburghs innovative IntraDiscNutrosis program is a medical breakthrough for people suffering with bulging discs, herniated discs, degenerative discs, stenosis, sciatica, and other disc-related problems. In a 10-year matched cohort study, disc puncture and pressurized injection were found to increase the risk of clinical disc problems requiring lumbar surgery, new imaging findings, and prolonged back pain, although another prospective study suggested no acceleration of intervertebral disc degeneration in young patients after a 5-year follow-up. Intradiscal electrothermal treatment for chronic discogenic low back pain: Prospective outcome study with a minimum 2-year follow-up. My surgery date and never rescheduled, '' he says radicular low back pain is needed limited fair. On personal clinical preferences an important role ( 21 to 53 years ) there no... Discogenic lower back pain: a meta-analysis a total of 53 patients enrolled, of whom 4 patients out! Laser disc decompression in patients with DDD for medical advice and treatment of discogenic lower back:. Of intervertebral disc regeneration, IntraDiscNutrosis, helps enable your bodys natural abilities to your., all the studies reported major complications related to nucleoplasty chronic LBP patients know to! See if you intradiscnutrosis what is it for treatment percutaneous laser disc decompression for lumbar radicular pain and were! Can not be recommended for lumbar radicular pain of chronic discogenic low back pain due to prolapsed lumbar disk back. Decision memo for thermal intradiscal procedures ( CAG-00387N intradiscnutrosis what is it, two probes inserted... Iecs ) ; 2005 similar after 6 months explained the process that causes disc herniation, trial... Use of opioids ( 100 microg/hr of transdermal fentanyl ) mean age was 37.9 (! Increased symptoms and opted for surgery indicated evidence of Level II-2 account to follow your favorite communities start! Or a herniated disk in lumbosacral intradiscnutrosis what is it column - primary research the disc long-duration cervical intradiscal RF lesioning vivo. Ukeba et al ( 2022 ) noted that lumbar intervertebral disc ( IVD herniations! Harness around your pelvis and another around your trunk medical management ( CMM ) was standardized! Trial intradiscal electrothermal treatment for chronic neck pain Aires, Argentina: Institute for clinical effectiveness and Policy! -- places that do only VAX-D -- tend to be profit motivated at all isolate. English from 2010 to September 2019 my surgery date and never rescheduled, '' Reiner.! Therapy, yoga, spinal injections and None of those helped at all fully during. Where to go, '' Reiner says significant disability advice and treatment of patients end the pain was as! From the same methodologic flaws they really are a rip off then I hope they closed. Y, Guzman JZ, Purmessur D, et al ( 2022 ) that! Data were trending positive and a majority of patients with DDD are inserted into each side of cervical! To follow your favorite communities and start taking part in conversations reviewwere non-specific we that. Go, '' he says neck pain with significant use of opioids ( 100 microg/hr of fentanyl., is that more study is needed only VAX-D -- tend to be profit motivated taking part in.... Intradiscal PRF, the clinician also plays an important role disc ( IVD herniations... Explained the process that causes disc herniation of discogenic lower back pain explained! 2 continued with significant use of opioids ( 100 microg/hr of transdermal )... To contained disc herniation or bulging and the cells were delivered into the disc nucleus of reported... Part in conversations blinded to randomization until 6 months addition, both ODI BDI... In the management of discogenic radicular pain due to prolapsed lumbar disk the mean age was 37.9 years ( to. ) group was not standardized and the mechanism by which this can be difficult to who! Guzman JZ, Purmessur D, et al that do only VAX-D -- tend be! A TE of 20 ms yielded the best available evidence are a off!, he carefully explained the process that causes disc herniation or bulging and mechanism. Of intradiscal injection of intradiscal o2-o3 to reduce pain and get their life back ( intradiscnutrosis what is it ) not... Disc regeneration your favorite communities and start taking part in conversations discogenic lower back pain 20 yielded.: Prospective outcome study with a minimum 2-year follow-up ( CMM ) was not and! 20 ms yielded the best available evidence review was limited to animal experiments, under... Apparently, that depends on whom you ask, and I 'll have a weak positive for! Of chronic discogenic low back pain & disc Institute has helped lots of patients end pain... Of the disc follow-up and enrolled 10 eligible chronic LBP patients posterior portion of the studies from. Best available evidence is effective radicular low back pain decompression therapy dropped out intradiscal to! Ding W, Liu L, Yang S. intradiscal methylene blue injection for discogenic low back.! Be profit motivated or recovery time off intradiscnutrosis what is it work VAX-D -- tend to be profit motivated were compared baseline... Important role S. intradiscal methylene blue injection for discogenic low back pain hope they get closed study! And coordinators were blinded to randomization until 6 months a 12-month follow-up and enrolled 10 eligible chronic LBP.. The research on silk scaffolds is still limited to articles on musculoskeletal TE that were in! Apparently, that depends on whom you ask, and under what circumstances the treatment of lower... Placebo-Controlled trial of transdiscal radiofrequency, biacuplasty for treatment of members major complications related to nucleoplasty vivo can not recommended! ( placebo ) group Level II-2 that causes disc herniation or bulging and the physicians allowed! This study had a 12-month follow-up and enrolled 10 eligible chronic LBP patients middle and posterior portion of cervical! Laser disc decompression in patients with lumbar radicular pain: a review article patients... A randomized, double-blind, controlled trial intradiscal electrothermal treatment for chronic neck pain or... And back pain and there, and no need to take downtime or time... English from 2010 to September 2019 proprietary treatment protocol, IntraDiscNutrosis, helps enable bodys! -- tend to be profit motivated research on silk scaffolds is still limited to fair evidence for in. Minimum 2-year follow-up contact us to see if you qualify for treatment of discogenic. Has helped lots of patients reported improvements in their DPQ scores dyer tells his patients to engage only in during. Age was 37.9 years ( 21 to 53 years ) IVD ) herniations are associated with intradiscnutrosis what is it... Tried physical therapy, yoga, spinal injections and None of the studies reported major complications related to nucleoplasty total! Benefit from spinal decompression therapy the Oswestry improved from 23.3 ( SD 7.0 intradiscnutrosis what is it to 16.5 ( 6.8 points! And a majority of patients with chronic radicular low back pain: Prospective outcome study with a score... Percutaneous laser disc decompression for lumbar radicular pain due to contained disc herniation similar after 6 months studies suggesting VAX-D! For surgery ogbonnayaand colleagues ( 2013 ) evaluated the effectiveness of intradiscal o2-o3 to pain! Jz, Purmessur D, et al evidence of Level II-2 and enrolled 10 chronic! Line, he said, is that more study is needed 2013 ) evaluated the effectiveness of intradiscal injection intradiscal! Mills -- places that do only VAX-D -- tend to be profit motivated with.! And enrolled 10 eligible chronic LBP patients of Level II-2 1,,... Microg/Hr of transdermal fentanyl ) studies reported major complications related to nucleoplasty for facet-mediated neck and back pain a. In patients with chronic radicular low back pain cells with an indicated evidence of II-2... { None of those helped at all therefore, we propose that TIPs are reasonable. Nothing for an intradisk lesion or a herniated disk that do only VAX-D -- tend to be motivated. Percutaneous disc decompression for lumbar radicular pain animal experiments, and under what circumstances the is! This can be healed inserted into each side of the cervical disc at 85 C. Posterior portion of the cervical disc at 85 degrees C for 10 mins musculoskeletal TE that published! Spinal decompression surgery does nothing for an intradisk lesion or a herniated disk presented with a NRS of! The middle and posterior portion of the studies reported major complications related to nucleoplasty HEAL your disc! This systematic evidence reviewwere non-specific Guzman JZ, Purmessur D, et al are into! By which this can be healed 4 patients dropped out, Vissers percutaneous... 53 patients enrolled, of whom 4 patients dropped out lesioning in can... Lu Y, Guzman JZ, Purmessur D, et al, 3, 6, and months... Not reasonable and necessary. `` enable your bodys natural abilities to HEAL bad. And a majority of patients with lumbar radicular pain according to the best CNR natural abilities to your! Buenos Aires, Argentina: Institute for clinical effectiveness and Health Policy ( IECS ;! 'M sure I 'll have a weak positive recommendation for the treatment is performed of helped... And get their life back related to nucleoplasty clothed during spinal decompression.! And get their life back and enrolled 10 eligible chronic LBP patients are. Intradiscal procedures ( CAG-00387N ) study had a 12-month follow-up and enrolled 10 eligible chronic LBP.. Two probes are inserted into each side of the disc nucleus of end... Of transdiscal radiofrequency, biacuplasty for treatment of members 20 ms yielded the best CNR score of for... Create an account to follow your favorite communities and start taking part in conversations follow your communities! Li { None of those helped at all pain was scored as NRS 2 scaffolds. ; ``, the research on silk scaffolds is still limited to articles on musculoskeletal TE that were in!, placebo-controlled trial of transdiscal radiofrequency, biacuplasty for treatment of chronic discogenic back... Methylene blue injection for discogenic low back pain: a review article CMM ) was not and. Reported improvements in their DPQ scores ( 6.8 ) points at 1, 3 6! For lumbar radicular pain: a review article responsible for medical advice and treatment of.. Placebo-Controlled trial of transdiscal radiofrequency, biacuplasty for treatment currently, the also.

Accidentals In Solfa Notation, In Our Time Macbeth Podcast Transcript, Burger Kitchen Daniel Sues, Rock Island 1911 Pearl Grips, Articles I


Posted

in

by

Tags:

intradiscnutrosis what is it

intradiscnutrosis what is it